Dr. 辛格’s laboratory studies molecular and cellular mechanisms of underlying immune
responses against pathogens and cancers. We utilize a variety of immunological, epigenetic,
molecular, biochemical, and cellular techniques to study the behavior of immune cells
during pathological conditions.
One of the ongoing projects in the laboratory involve studying the development, survival,
and function of plasma cells. Plasma cells are factory for producing antibodies molecule
that neutralize the invading pathogens. Understanding of these mechanisms is critical
in designing improved vaccines against pathogens.
His other research interest includes how T cells are activated and generate immune
responses and help other immune cells to successfully eliminate invading pathogens
and cancers. Under this project, he is studying how T cells become exhausted or toothless
during chronic infection and cancers.
Previously, he discovered the mechanism underlying dietary fiber mediated induction
of anti-inflammatory mechanisms in intestine such as Treg cells leading to suppression
of intestinal inflammation and cancers.
他的研究由NIH/NIAID等校外资源资助。
选择出版物:
Yang W, Yu T, Huang X, Bilotta AJ, Xu L, Lu Y, Sun J, Pan F, Zhou J, Zhang W, Yao
S, Maynard CL, 辛格N, Dann SM, Liu Z, Cong Y. Intestinal microbiota-derived short-chain fatty acids regulation
of immune cell IL-22 production and gut immunity. 自然 通信 9月8日；11(1):4457（2020）。 doi: 10.1038 / s41467 - 020 - 18262 - 6。PMID:32901017.
ZhuH, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma
A, Kaufman RJ,Li H and 辛格N。 Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches
of UPR. 自然通讯 3月6日10(1):1084（2019）。
Bhatt B, Zeng P, Zhu H, Sivaprakasam S, Li S, Xiao H, Dong L, Shiao P, Kolhe R, Patel
N, Li H, Levy-Bercowski D, Ganapathy V, 辛格N。 Gpr109a Limits Microbiota-Induced IL-23 Production to Constrain ILC3-Mediated Colonic
Inflammation. J免疫学 2018年3月7日。 [印前Epub] PMID: 29514953。
Zhu H, Lemos H, Bhatt B1, Islam BN, 辛格 A, Gurav A, Huang L, Browning DD, Mellor A, FulzeleS and 辛格N. Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation
and autoimmunity. 《公共科学图书馆•综合》 Sep 12;12(9):e0183484（2017）。
SivaprakasamS, GuravA, V Paschall A, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang
L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao
P, Cutler CW, Liu K, Ganapathy V, Li H, and 辛格N. An essential role of Ffar2 (Gpr43) in dietary fibre mediated promotion of healthy
composition of gut microbiota and suppression of intestinal carcinogenesis. 肿瘤形成 5, e238 (2016)； doi: 10.1038 / oncsis.2016.38
Cai Y, Pi W, Sivaprakasam S, Zhu X, Zhang M, Chen J, Makala L, Lu C, Wu J, Teng Y,
Pace B, Tuan-Lo D, 辛格 N *, Li H*. Indispensable role of the Ufm1 conjugation system in hematopoietic stem cell
survival and erythroid development. 公共科学图书馆麝猫. 11: e1005643(2015)。 (*相应的作者)
辛格N *, GuravA, SivaprakasamS, BradyE, PadiaR, ShiH, Thangaraju M, Prasad PD, ManicassamyS, Munn DH, LeeJR, OffermannsS, & Ganapathy V*. Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite
Butyrate, Suppresses Colonic Inflammation and Carcinogenesis.免疫力 40:128 (2014) PMID: 24412617 (*相应的作者)
Zhang M, Zhu X, Zhang Y, Cai Y, Chen J, Sivaprakasam S, Gurav A, Pi W, Makala L, Wu
J, Pace B, Tuan-Lo D, Ganapathy V, 辛格N * and Li H*. RCAD/Ufl1, an Ufm1 E3 ligase, is essential for hematopoietic stem cell
function and murine hematopoiesis. 细胞死亡不同。 12月22日1922（2015）。 (*相应的作者)
辛格N, Yamamoto M, Takami M, Seki Y, Takezaki M, Mellor AL, and Iwashima M. CD4+CD25+ regulatory
T cells resist a novel form of CD28-and Fas-dependent p53-induced T cell apoptosis.
J免疫学 184:94（2010）中号：19949106
辛格N, Chandler PR, Seki Y, Baban B, Takezaki M, Kahler DJ, Munn DH, Larsen CP, Mellor
AL, and Iwashima M. Role of CD28 in fatal autoimmune disorder in scurfy mice. 血 [110:1199(2007)]中号：17463170
辛格N, Seki Y, Takami M, Seki Y, Baban B, Chandler P, Khosravi D, Zheng X, Takezaki M,
Lee JR, Mellor AL, Bollag W and Iwashima M. Enrichment of regulatory CD4+CD25+ T cells
by inhibition of phospholipase D signaling. 自然的方法 3:629（2006）中号：16862138
